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Dear Colleague, Please find information about two upcoming courses arranged by the Swedish Academy of Pharmaceutical Sciences. Introduction to Quantitative Pharmacology and PK/PD for Drug Discovery & Development Scientists, Munich, Germany, September 2-3, 2010 This course aims to give the delegates confidence and encouragement to have a go at PKPD and to build relationships between bioscience, DMPK, medicinal chemistry and related scientific disciplines. The programme is comprised of lectures and afternoon group exercises. Course objectives * To raise awareness amongst bioscience, medicinal chemistry and clinical scientists of what kinetic-dynamic (PKPD) methods can offer * To raise awareness of the individual steps that makes up the dose-plasma-distribution-binding-turnover- response process * To raise awareness of experimental design. What investment has to be done early and late in discovery? * To build a case for the assessment of the first time in man dose * To provide theory and methods of in vivo PKPD data Who should attend? Bioscience, safety, medicinal chemistry and clinical scientists, statisticians, pharmacokineticists, pharmacologists etc. Topics * PK from a PD point of view * PK half-life vs. half-life of response * The apparent disconnection between PK and PD * Emax-models and their difficulties if maximum response is lacking * Effect compartment models in (distribution-rate limited) responses * Turnover models in (turnover-rate limited) responses * Receptor on/off binding models in (binding-rate limited) responses * Scaling pharmacodynamics and PK properties to man * Practical experimental design of PD studies * PKPD assessment at milestone decisions For further information, please visit our website: www.lakemedelsakademin.se/munich The 17th Intermediate Workshop on PK/PD Data Analysis: A Hands-on Course Using WinNonlin, Rome, Italy, September 26-30, 2010 Course outline Morning sessions consist of lectures dealing with choice of weights, goodness-of-fit, interpretation of computer output, experimental design and discrimination between rival models. Afternoon sessions are devoted to applying the methods discussed in the lectures to actual data, using WinNonlin. One afternoon session will be given as an introduction for participants with no, or very little, experience with WinNonlin. The participants work on their own laptops during the hands-on sessions. Who should attend? This workshop is intended for individuals engaged in the pharmaceutical industry, regulatory agencies, contract research companies and universities and for others who want to learn the aspects of model fitting. Previous participants have been toxicologists, kineticists, bioanalytical chemists, pharmacologists, clinical pharmacologists, anaesthesiologists, clinical research assistants and scientists from academia and regulatory agencies. Participants should have a background in pharmacokinetics but those with limited experience would also benefit. The number of participants is limited. Topics *Introduction and overview *Assessment of goodness of fit *Pharmacodynamic issues *Design of experiments *Comparison of models For further information, please visit: www.lakemedelsakademin.se/17th With kind regards, Annica Flodin, Projektadministratör/Project Administrator Läkemedelsakademin Box 1136, 111 81 Stockholm, Sweden Besöksadress: Wallingatan 26A Tel. 08-723 50 40; Fax 08-20 55 11 E-mail: [email protected] <mailto:[email protected]> Hemsida: www.lakemedelsakademin.se http://www.lakemedelsakademin.se/ <<image003.jpg>>