PD model

Dear All, I am looking for a help. Currently I am working on a population PD model to evaluate the effects of drugs on QT prolongation. Drug A and drug B are given to the study subjects (healthy volunteer) at the same time. Drug B is the inhibitor for the metabolism of drug A, also compound C is the metabolite of drug A. I am wondering how to evaluate the effects for drug A or B or the metabolite of drug A (compound C). These three moieties will be present together in the blood for most of the time. Is anyone has experience and would like to share with us. Any comment will be greatly appreciated. Best regards, Yuhong ____________________________________________________________ Diet Help Reach your goals of being healthier and happier. Click here for diet tips and solutions. http://thirdpartyoffers.netzero.net/TGL2241/c?cp=0TyE90NYD1UWB77GnvM8cgAAJ1EqI3_TpApLLwjS4plsTl0gAAYAAAAAAAAAAAAAAAAAAADNAAAAAAAAAAAAAAAAAAAYQAAAAAA=