$ERROR and LOGIT
Hello,
NONMEM has the following property related to intra-subject variability:
"During estimation by the first-order method, the exponential model and
proportional models give identical results, i.e., NONMEM cannot distinguish
between them." So, NONMEM transforms F*DEXP(ERR(1)) into F + F*ERR(1).
Is there an easy around it? I try to code the logit transformation. I cannot
log-transform the original data as it is suggested in some publications
including the presentation by Plan and Karlsson (Uppsala) because many values
will be equal to plus or minus infinity. Will NONMEM "linearize" the following
code:
Z = DLOG((F+THETA(10))/(1-F+THETA(10)))
Y = DEXP(Z + ERR(1))/(1 + DEXP(Z + ERR(1)))
Thanks!
Pavel