Re: Deat Jun,the covariance?
Dear Hongpo
Covariance between CL and V etas can be or should be observed for the oral
route. CL and V are apparent parameters that are related by the unknown
bioavailability : these are CL/F and V/F, so there is a
physiological/pharmacological basis for the correlation.
Saik
----- Original Message -----
Quoted reply history
From: yhb5442387
To: nmusers
Sent: Monday, December 14, 2009 4:10 PM
Subject: [NMusers] Deat Jun,the covariance?
Dear Jun:
Sorry for making you in the reading trouble:
Here is my question:
Is there any special specification on the employ of covariance:
The papers which I have read most always take the covariance excluded,such as
W21,w31 w32.If the Decrease of OFV between the model of the covriance included
and the one not is significantly meaningful,what choice should I do? I really
do not understand the correlation of Cl and V,if the convariance between the
two parameters does exist.Dose it truly exist in physiologically or just
mathematically?
Dear Hongpo,
I am not sure I understand your question. Can you rephrase?
Jun Shen
Millipore Corporation
2009/12/13 yhb5442387 <[email protected]>
Dear professor:
THE off diagnoal:
Sometimes we make the OMEGA syntax as follows:$omega 0.1 0.1,but $omega
blokc (2) 0.1 0.01 0.1 at another occasion.As we know,the only difference is
whether the off diagonal estimate be used.So is there any specila condition
about the existence of the W21,or some another W square like that?
Thank you !!!
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