Release PsN version 3.1.0

Dear PsN users, PsN 3.1.0 is now available for download from http://psn.sourceforge.net The most important changes since 3.0.0 are a completely rewritten parser for THETA/OMEGA/SIGMA and significantly extended NONMEM7 support. Best regards, Sebastian Ueckert ****************************** ******* Changes from PsN 3.0.0 to 3.1.0 ***New documentation*** - The document PsN_and_NONMEM7.pdf describes how PsN deals with the many new features and functions of NONMEM7. This document is essential for anyone who intends to use PsN with NONMEM7. ***New features 3.1.0*** - Extensive NONMEM7 support. All PsN tools accept modelfiles with multiple $ESTIMATION. All estimation methods are supported. Please note: only results from last $EST will be presented and used in data processing. - New parser for THETA, OMEGA and SIGMA. With the new parser all known bugs are removed. All formatting variants described in the NONMEM userguide are supported. - tweak_inits will ensure that OMEGA and SIGMA are strictly diagonally dominant. This reduces the risk of NONMEM halting due to non-postive definite initial estimate matrices. Also, tweak_inits will not change initial estimates that are zero, regardless if they are FIXED or not. This preserves band matrices. - New options -predcorr (prediction correction) and -varcorr (variability correction, experimental) to vpc. More details in the vpc userguide. - New options -last_est_complete and -niter_eonly for tools that run some models with skipped estimation step (cdd, npc, vpc, execute with mirror_plots option). More details in PsN_and_NONMEM7.pdf. - update_inits now has options for renumbering output files in $TABLE and adding comments in $PROBLEM - Both run information files version_and_option_info.txt and command.txt will be overwritten at each rerun in the same PsN directory, also for npc and vpc. The files from the original PsN call are saved as original_command.txt and original_version_and_option_info.txt - The logic for the flag minimization_successful has been adapted to new the estimation methods. Affects retries and sumo output. More details in PsN_and_NONMEM7.pdf - For developers only: Many accessors to the output object have changed. Contact the PsN development team for more information. Sebastian Ueckert, MSc, PhD student ----------------------------------------------- Pharmacometrics Research Group, Department of Pharmaceutical Biosciences, Uppsala University ----------------------------------------------- P.O. Box 591 SE-751 24 Uppsala Sweden ----------------------------------------------- [email protected] ----------------------------------------------- Work: +46-(0)18-471 4291