NMUSERS-modeling dose and response

Dera NMUSERS: I have a dataset where an anticoagulant has been administered and the response measured as unils/mL. Due to the inherent difficulty associated with measuring plasma concentrations of this drug no such measurements are available. I am interested in determining the population PK of this agent and connecting the dose size to response. Should I be using a linked PK-PD model? Can I use the response values in u/mL instead of plasma concentrations? Which model in the NONMEM library should I start with ADVAN 5 or 6? Thanks in advance!! Varsha Varsha Mehta, MS(CRDSA), Pharm.D., FCCP Clinical Associate Professor Pharmacy, Pediatrics and Communicable Diseases Clinical Pharmacist Neonatal Critical Care University of Michigan (O) 734-936-8985 (F) 734-936-6946 [email protected] ********************************************************** Electronic Mail is not secure, may not be read every day, and should not be used for urgent or sensitive issues