ftp availability of PDx-Pop 4 for NONMEM 7

PDx-Pop 4 for NONMEM 7 is now available for all platforms (Windows, Linux and Mac OS X) via our ftp site at ftp://ftp.globomaxnm.com/Public/pdxpop/PDX-Pop4.0/. In order to make PDx-Pop 4 for NONMEM 7 quickly available to our PDx-Pop users who already have NONMEM 7, the software may be downloaded for immediate use. Your existing PDx-Pop 3 license file can be used with PDx-Pop 4 (and both versions of the software may be used as you transition from NONMEM VI to NONMEM 7). Distribution CD-ROM's will be available at a later date. A final revised version of PDx-Pop 3.x for NONMEM VI will also be made available via ftp later this month. The software may also be downloaded for trial use by all licensed NONMEM 7 users. All features of PDx-Pop 4 in trial use are enabled but PDx-Pop 4 will cease to work after 30 days if the PDx-Pop 4 software is not licensed. PDx-Pop Version 4.0 for NONMEM 7 Release Notes October 15, 2009 New Features in Version 4.0: 1. Real-time graphical monitoring of the objective function for all of the new estimation methods (including the Bayesian chain "caterpillar" plot and composite method runs) 2. Button-operated interaction with the NONMEM run: - toggle on-off printing of numerical iteration (Iterations) - gracefully end a problem (Next) - end NONMEM run gracefully (Stop) 3. Extended Summary Output (added features): - list of all estimation methods used in the run - statistical summary from final method 4. Multi-CPU capability to run NONMEM batchs simultaneously (on multi-CPU systems) 5. Graphical display of parameter sampling histories from Bayesian method 6. Automated setup and run of multiple MCMC chains (with randomized initial parameter estimates) simultaneously 7. Graphical display of multiple chains output (overlay plots of parameter histories and statistical summary from multiple MCMC chains) 8. Automated initial parameter variation test (simultaneous runs with randomized initial parameters) 9. New control file wizard to automate creation of control files including: - new estimation methods coding and options - composite methods (runs with multiple estimation methods) - automatic mu parameterization for library methods (ADVANS 1-4,10-12) - optional inclusion of error code for IPRE, IRES, IWRE 10. PDx-Pop can now run user-written S-Plus and R scripts that can be linked to a specified run to create automated custom output. Free 30-day trial versions (with all features enabled) are available from our FTP site: ftp://ftp.globomaxnm.com/Public/pdxpop/PDX-Pop4.0/ (Use of PDx-Pop 4 requires a licensed copy of NONMEM 7.) See the PDx-Pop 4 Manual for installation instructions. NONMEM 7 and PDx-Pop 4 operation was designed for Intel Fortran 8.0 and higher, g95 and GNU gfortran. William J. Bachman, Ph.D. Director, Pharmacometrics R&D Icon Development Solutions 6031 University Blvd., Suite 300 Ellicott City, MD 21043 Office 215-616-8699 Cell 301-467-8635 [email protected]