method=ITS, OPTIMIZATION NOT TESTED (?!)
Hello NONMEM Team,
I found method=imp useful when there are local maxima. Nevertheless, at the
end of optimization it prints a message, which makes me feel somewhat
uncomfortable: OPTIMIZATION NOT TESTED. Also, the final objective function is
not always the lowest one. An example is below. How do we interpret the
results in this case?
THETAS THAT ARE SIGMA-LIKE:
MONITORING OF SEARCH:
iteration 0 OBJ= 10625.663135214874
iteration 1 OBJ= 10601.188754983375
iteration 2 OBJ= 10537.895114114934
iteration 3 OBJ= 10471.674625518765
iteration 4 OBJ= 10430.297437731866
iteration 5 OBJ= 10461.973668565577
iteration 6 OBJ= 10462.638834406265
iteration 7 OBJ= 10423.464983371641
iteration 8 OBJ= 10417.959956991735
iteration 9 OBJ= 10417.594007447198
iteration 10 OBJ= 10414.708468642830
iteration 11 OBJ= 10427.810693855947
iteration 12 OBJ= 10412.889081059604
iteration 13 OBJ= 10411.980622268416
iteration 14 OBJ= 10424.501127174915
iteration 15 OBJ= 10416.332869468861
iteration 16 OBJ= 10416.622580251338
iteration 17 OBJ= 10412.401585537709
iteration 18 OBJ= 10415.117257355550
iteration 19 OBJ= 10415.302370961055
iteration 20 OBJ= 10409.066188189252
iteration 21 OBJ= 10413.780620468329
iteration 22 OBJ= 10410.787496174480
iteration 23 OBJ= 10410.633582415931
iteration 24 OBJ= 10409.970257443048
iteration 25 OBJ= 10409.702420124611
iteration 26 OBJ= 10409.213115058612
iteration 27 OBJ= 10409.690639357370
iteration 28 OBJ= 10410.016047785200
iteration 29 OBJ= 10408.157468814226
iteration 30 OBJ= 10407.779614704938
iteration 31 OBJ= 10410.164563157052
iteration 32 OBJ= 10408.364552302961
iteration 33 OBJ= 10407.431920727997
iteration 34 OBJ= 10408.286189641487
iteration 35 OBJ= 10407.907347050501
iteration 36 OBJ= 10407.451608770069
iteration 37 OBJ= 10407.189482360372
iteration 38 OBJ= 10406.484357336147
iteration 39 OBJ= 10409.167125968375
iteration 40 OBJ= 10406.840873883246
iteration 41 OBJ= 10407.679485561714
iteration 42 OBJ= 10405.341101045238
iteration 43 OBJ= 10404.704382334516
iteration 44 OBJ= 10405.348023082915
iteration 45 OBJ= 10405.347406984720
iteration 46 OBJ= 10401.873473651774
iteration 47 OBJ= 10404.036204419035
iteration 48 OBJ= 10405.072916975221
iteration 49 OBJ= 10402.976628923887
Elapsed estimation time in seconds: 30420.73
iteration 50 OBJ= 10403.285958168881
#TERM:
OPTIMIZATION NOT TESTED
Thanks,
Pavel