RE: implementation of prior subroutine

________________________________ From: [email protected] [mailto:[email protected]] On Behalf Of [email protected] Sent: Friday, September 04, 2009 05:15 To: [email protected] Subject: [NMusers] implementation of prior subroutine Dear all, first of all I would like to thank all the people who took the time to answer my last question. It really helped understanding the problem. However, I already have a next problem :-) I am trying to implement the prior subroutine in NONMEM for a first time, using NONMEM VI level 1.0. I have created a file named prior.for which looks the following: SUBROUTINE PRIOR (ICALL,CNT) DOUBLE PRECISION CNT NTHETA=6 NETA=6 NTHP=6 NETP=6 NPEXP=1 PLEV=0 CALL NWPRI (NTHETA,NETA,NEPS,NTHP,NETP,NEPP,NPEXP,ITYP,PLEV, 1 NSAM,ISS,CNT) RETURN END When trying to run my model with new data, I get the following error message: S:1 .. Fatal Error: Fortran Compilation failed: FSUBS.f:1: SUBROUTINE PRIOR (ICALL,CNT) ^ Invalid first character at (^) [info -f g77 M LEX] at /usr/share/perl/5.10.0/PsN_2_3_1/nonmem.pm line 27 Can anybody point me to the error? Moreover, I have a question concerning the prior information on parameter uncertainty. I got an error message when implementing the values as seen in the NONMEM output file (e.g. 2.22E-05), however when implementing them as presented in the model file below, I get a problem with the allowed number of digits. How do I get the correct values in there? My model file looks like the following: $PROB PK - Model $INPUT C ID DOSE AMT ADDL II TIME DV EVID MDV AGE SEX WT $DATA example.CSV IGNORE=C $SUBROUTINES PRIOR=../../prior.for $SUBROUTINES ADVAN4 TRANS4 $PK TVA0 = THETA(1) ALAG1 = TVA0 * EXP(ETA(1)) TVK0 = THETA(2) KA = TVK0 * EXP(ETA(2)) TVCL0 = THETA(3) CL = TVCL0 * EXP(ETA(3)) TVV20 = THETA(4) V2 = TVV20*EXP(ETA(4)) Q = THETA(5)*EXP(ETA(5)) V3 = THETA(6)*EXP(ETA(6)) TVF0 = 1 F1 = TVF0 S2=V2/1000 K=CL/V2 K23=Q/V2 K32=Q/V3 $ERROR W = THETA(13) IPRED = LOG(F+1E-10) Y=IPRED + W*EPS(1) IRES = DV - IPRED IWRES = IRES / W $THETA (0.10) ;1 ALAG1 (0.50) ;2 KA (10.0) ;3 CL (10.0) ;4 V2 (20.0) ;5 Q (100) ;6 V3 (0, 0.25) ;7 CV $OMEGA DIAGONAL(4) 0.10 ; VAR(ALAG1) 0.10 ; VAR(KA) 0.10 ; VAR(CL) 0.10 ; VAR(V2) $OMEGA BLOCK(2) 0.10 ; VAR(Q) 0.010 0.10 ; VAR(V3) $SIGMA 1 FIXED $THETA 0.1 FIX ;prior on ALAG $THETA 0.5 FIX ;prior on KA $THETA 10 FIX ;prior on CL $THETA 10 FIX ;prior on V2 $THETA 20 FIX ;prior on Q $THETA 100 FIX ;prior on V3 $OMEGA BLOCK(12) 0.000019 0.000012 0.000273 0.000064 0.000023 0.222000 0.001050 0.003400 0.014900 0.942000 -0.000531 0.000103 -0.01280 -0.029203 0.170000 -0.005452 -0.000972 -0.291002 -0.587002 1.150000 23.100000 $OMEGA 0.1 FIX ;prior on IIV_ALAG $OMEGA 0.1 FIX ;prior on IIV_KA $OMEGA 0.1 FIX ;prior on IIV_CL $OMEGA 0.1 FIX ;prior on IIV_V2 $OMEGA BLOCK(2) 0.1 ;prior on IIV_Q 0.01 0.1 FIX ;prior on IIV_V3 $THETA 2 FIX ;d.f. ALAG $THETA 2 FIX ;d.f. KA $THETA 2 FIX ;d.f. CL $THETA 2 FIX ;d.f. V2 $THETA 2 FIX ;d.f. Q $THETA 2 FIX ;d.f. V3 $EST METHOD=HYBRID ZERO=(1) SIGDIGITS=3 MAXEVAL=9999 PRINT=5 NOABORT MSFO=msf001 $COV MATRIX=R PRINT=E $TABLE ID TIME DOSE IPRED IWRES NOPRINT ONEHEADER FILE=sdtab001 Thanks and best regards Nele ______________________________________________________________ Dr. Nele Käßner Pharmacometrics -- Modeling and Simulation Nycomed GmbH Byk-Gulden-Str. 2 D-78467 Konstanz, Germany Fon: (+49) 7531 / 84 - 4759 Fax: (+49) 7531 / 84 - 94759 mailto: [email protected] http://www.nycomed.com County Court: Freiburg, Commercial Register HRB 701257 Chairman Supervisory Board: Charles Depasse Management Board: Dr. Barthold Piening, Gilbert Rademacher, Dr. Anders Ullman ---------------------------------------------------------------------- Proprietary or confidential information belonging to Nycomed Group may be contained in this message. 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