PDx-Pop 4 for NONMEM 7

With the recent release of NONMEM 7, we are proud to announce the upcoming new release of our graphical interface, PDx-Pop Version 4.0, specifically designed for NONMEM 7 and above. (PDx-Pop 3.x was designed for, and operates with, NONMEM V and VI.) New features available with PDx-Pop 4 include: 1. Real-time graphical monitoring of the objective function for all of the new estimation methods (including the Bayesian chain "caterpillar" plot and composite method runs) 2. Button-operated interaction with the NONMEM run: - toggle on-off printing of numerical iteration (Iterations) - gracefully end a problem (Next) - end NONMEM run gracefully (Stop) 3. Extended Summary Output (added features): - list of all estimation methods used in the run - statistical summary from final method 4. Multi-CPU capability to run NONMEM batchs simultaneously (on multi-CPU systems) 5. Graphical display of parameter sampling histories from Bayesian method 6. Automated setup and run of multiple MCMC chains (with randomized initial parameter estimates) simultaneously 7. Graphical display of multiple chains output (overlay plots of parameter histories and statistical summary from multiple MCMC chains) 8. Automated initial parameter variation test (simultaneous runs with randomized initial parameters) 9. New control file wizard to automate creation of control files including: - new estimation methods coding and options - composite methods (runs with multiple estimation methods) - automatic mu parameterization for library methods (ADVANS 1-4,10-12) - optional inclusion of error code for IPRE, IRES, IWRE Estimated distribution date: Late October 2009 All licensed PDx-Pop users will receive the new PDx-Pop 4 distribution CD-ROM. Free 30-day trial versions (with all features enabled) will be available from our FTP site. (Use of PDx-Pop requires a licensed copy of NONMEM.) An update of PDx-Pop 3, version 3.2, will also be available later this year. PDx-Pop 3.2 will contain many of the new features found in PDx-Pop 4.0. The update will be downloadable from our FTP site at that time. William J. Bachman, Ph.D. Director, Pharmacometrics R&D Icon Development Solutions 6031 University Blvd., Suite 300 Ellicott City, MD 21043 Office 215-616-8699 Cell 301-467-8635 [email protected]