Re: time-dependent residual error models

Hi, If Phylinda reads this I'd be interested to hear why she choose to use a plain vanilla first-order absorption model and a fancy time-dependent residual error model rather than trying to model a fancy absorption process with a plain vanilla residual error model? Nick Joseph Standing wrote: > Xiang, > > There is a rather elegant time-dependent residual error model described by Phylinda Chan et al in: > > BJCP, 2008;65(S1):76-85. > > BW, > > Joe -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand [email protected] tel:+64(9)923-6730 fax:+64(9)373-7090 mobile: +64 21 46 23 53 http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford