RE: change calculation of WRES?

Van: [email protected] [mailto:[email protected]] Namens [email protected] Verzonden: dinsdag 25 augustus 2009 14:21 Aan: [email protected] Onderwerp: [NMusers] change calculation of WRES? Dear nmusers, I have a question which I hope is not too trivial for the group. I am currently analyzing some data where I have more trust in values at late time points. Therefore, I would like WRES to be a function of time, putting more weight on late time points. In the help guide I found that WRES can be influenced by SPTWO, however no real documentation exists (or I am not aware of it) about how to use it. Does anybody have an example for me of how to code this? Moreover, I noticed that no matter how I describe my weighting for IWRES, this does not at all seem to influence my objective function or parameter values. When evaluating a model, most people consider anyway that WRES is what counts, as IWRES are in most cases ok anyway. So my very simple question is: If this does not influence any of this and I don't use IWRES to decide if a model is good or bad, why bother at all to calculate them? I noticed that the standard errors seem to change depending on which weighting I use for IWRES. Can anybody explain this? Thanks and best wishes Nele ______________________________________________________________ Dr. Nele Käßner Pharmacometrics -- Modeling and Simulation Nycomed GmbH Byk-Gulden-Str. 2 D-78467 Konstanz, Germany Fon: (+49) 7531 / 84 - 4759 Fax: (+49) 7531 / 84 - 94759 mailto: [email protected] http://www.nycomed.com County Court: Freiburg, Commercial Register HRB 701257 Chairman Supervisory Board: Charles Depasse Management Board: Dr. Barthold Piening, Gilbert Rademacher, Dr. Anders Ullman ---------------------------------------------------------------------- Proprietary or confidential information belonging to Nycomed Group may be contained in this message. If you are not the addressee indicated in this message, please do not copy or deliver this message to anyone. In such case, please destroy this message and notify the sender by reply e-mail. Please advise the sender immediately if you or your employer do not consent to Internet e-mail for messages of this kind. Opinions, conclusions and other information in this message that pertain to the sender's employer and its products and services represent the opinion of the sender and do not necessarily represent or reflect the views and opinions of the employer. ---------------------------------------------------------------------- ***************************DISCLAIMER**************************** De informatie in dit e-mail bericht is uitsluitend bestemd voor de geadresseerde. Verstrekking aan en gebruik door anderen is niet toegestaan. Door de elektronische verzending van het bericht kunnen er geen rechten worden ontleend aan de informatie.