Simulations with/without residual error

Dear NMUSERS, The recent discussion about simulation with a nonparametric method brought a general question concerning monte-carlo simulations into my mind. When should simulations be performed with residual error and when not. I am especially interested in comments regarding the following scenarios when the result of the simulation should be reported as mean or median and 90% prediction interval: 1. Simulated response at a particular time point (eg. Trough values) 2. Simulated response at a particular time point (x) relative to baseline response (IPRED(t=x)/IPRED(t=0) vs. DV(t=x)/DV(t=0) ) 3. Simulated time of maximal response (eg. Tmax) Thanks and best regards, Andreas. ____________________________ Andreas Lindauer Department of Clinical Pharmacy Institute of Pharmacy University of Bonn An der Immenburg 4 D-53121 Bonn phone: + 49 228 73 5781 fax: + 49 228 73 9757