Coding a triple absorption model
> Dear NMusers,
I am using a dual absorption model as follows (The dose is split into 2
fractions and the splitting fraction, THETA(.), is an estimated parameter in
the model):
TPH = LOG(THETA(.)/(1-THETA(.)))
TH = EXP(TPH+ETA(.))/(1+EXP(TPH+ETA(.)))
F2 = TH
F1 = 1-TH
However, upon prolonged sampling we can observe a 3rd shallow phase. I would
like to use a 3-depot absorption process with F1, F2 and F3=1-F1-F2. Both F1
and F2 need etas using some type of transformation such that neither one of
them exceed 1 nor does their sum exceed 1. Can some one kindly provide the
NONMEM code.
Thanking you in advance,
Mahesh