Exiting position in the Pharmacometrics group at GSK

Senior Statistical Modeller Location: Research Triangle Park (RTP), NC USA or Harlow, UK At GSK, within the newly created Pharmacometrics (PMx) group, have an opportunity for a senior Statistical Modeller. The candidate will be responsible for implementing innovative analytical methods to interpret and describe pharmacology, physiology and disease in a quantitative fashion by integrating and applying statistical models to characterize, understand, gain insights into the determinants of efficacy and safety outcomes, predict a drug?s and biomarker-outcome, optimize drug development plans and enable critical decision making. Responsibilities will include evaluating and applying new statistical methodologies and/or advanced study design to improve information quality and utility, and enhance efficiency of clinical trials. The candidate will have the opportunity to explore, learn and utilize state-of-the-art methodologies to help shape our question-based product development plans and aid in dose selection. The candidate will be advising colleagues on statistical modelling and simulation methodologies. The candidate will be working across the GSK drug discovery pipeline from pre-candidate selection through post-licensing within therapeutically-aligned groups. Qualification: The candidate should have an extensive statistical modelling and simulation skill set covering aspects of the following: Design and analysis of Phase II/III clinical trials, Disease progression modelling, Meta-data models utilising internal and external sources, Bayesian Statistics, Decision Analysis and Clinical trial simulation PhD in Statistics and/or Mathematics. A strong background in Bayesian statistics is recommended. Understanding of pharmacokinetics/dynamics and population modeling methods. Advanced awareness in optimal designs and adaptive designs. Computer/software proficiency supporting data analysis, including familiarity with R/S-Plus, BUGS, SAS and/or NONMEM. Good written and oral communication skills Knowledge of regulatory guidelines pertaining to drug development, statistics and M&S Team-oriented, self-motivated, innovative If you are interested in this position please visit www.gsk.com/careers quoting Req ID 54038. If you want more information about the position please contact Roberto Gomeni, Head Pharmacometrics: roberto.a.gomeni