Re: Imaginary concentrations

Hi, The OFV is computed using all observations. If you imagine an observation at time 0 then it will change the OFV. So my advice is not to imagine concentrations with MDV=0 but just use the concentrations you really measured. Nick ke fang wrote: > Hi! > Dear all! > My samples were collected after a single intramuscular injection. One > individuals provies only one tissue samples within the whole study. I found > the MOFV were quite different between the MDV was used or not. > > In my opinion, the concentration in tissue at T0 must be 0 because of the > intramuscular administration. So the concentration at T0 was not a real > observed 0 but a assumed 0. The question was that if i treated the T0 > concentration as a MDV, the MOFV was quite different from treating it as a > real obesrved concentration. > > Whether the MDV should be used in my case? Can anyone help me with this > problem? > > Thanks in advance! > > > Fang Ke > > > ___________________________________________________________ > 好玩贺卡等你发，邮箱贺卡全新上线！ > http://card.mail.cn.yahoo.com/ > -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand [email protected] tel:+64(9)923-6730 fax:+64(9)373-7090 mobile: +33 64 271-6369 (Apr 6-Jul 17 2009) http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford