Re: When is F1 Evaluated

Bill, F1 is evaluated at the instant that AMT enters CMT=1. If you want to modify F during absorption you will need to use something like this: $DES DADT(1) = -KA*A(1) ; gut loss (F1 will affect the AMT entering this CMT at the time of AMT record) FT=a+ b*A(1) ; some function of amount in CMT=1 DADT(2) = FT*KA*A(1) - CL*A(2)/V ; FT is a time varying fraction of the rate entering CMT=2 Nick Denney, William S. wrote: > Hello, > > When is F1 evaluated? I am working on a model with nonlinear bioavailability and I need to know if F1 is evaluated during the entire absorption process or if it is evaluated upon the dose entering the dosing compartment. > > Thanks, > > Bill > > Notice: This e-mail message, together with any attachments, contains > information of Merck & Co., Inc. (One Merck Drive, Whitehouse Station, > New Jersey, USA 08889), and/or its affiliates (which may be known > outside the United States as Merck Frosst, Merck Sharp & Dohme or > MSD and in Japan, as Banyu - direct contact information for affiliates is > available at http://www.merck.com/contact/contacts.html) that may be > confidential, proprietary copyrighted and/or legally privileged. It is > intended solely for the use of the individual or entity named on this > message. If you are not the intended recipient, and have received this > message in error, please notify us immediately by reply e-mail and > then delete it from your system. -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand [email protected] tel:+64(9)923-6730 fax:+64(9)373-7090 mobile: +33 64 271-6369 (Apr 6-Jul 17 2009) http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford