covariate-based dose prediction

From: Khaled Nm Date: April 30, 2009 technical Source: mail-archive.com

Dear nmusers, Could anyone tell me how i can predict the required dose of a drug at steady state based on final sequential PK/PD estimates from NONMEM. If I assume for example a target PD value of INR is 2.5. VKORC1 (and CYP2C9 polymorphism and AGE) affect PD (and PK) profiles. Thanks in advance Best Regards khaled

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