var-cov matrix issue?
Dear all,
I recently encounter this error message (below). My objective was to use
nonmem var-cov output for approximation of distribution of parameters for
performing a simulation.
if such error message occur, is the var-cov matrix still OK to use?
-- I know that better way to figure out distribution of parameters is to do
bootstrap, but given limited time I have....
thanks
"0MINIMIZATION SUCCESSFUL
NO. OF FUNCTION EVALUATIONS USED: 331
NO. OF SIG. DIGITS IN FINAL EST.: 3.3
ETABAR IS THE ARITHMETIC MEAN OF THE ETA-ESTIMATES,
AND THE P-VALUE IS GIVEN FOR THE NULL HYPOTHESIS THAT THE TRUE MEAN IS 0.
ETABAR: 0.11E-02
SE: 0.23E-01
P VAL.: 0..96E+00
0S MATRIX ALGORITHMICALLY SINGULAR
0S MATRIX IS OUTPUT
0INVERSE COVARIANCE MATRIX SET TO RS*R, WHERE S* IS A PSEUDO INVERSE OF S
1
"