Metrum Institute 2009 Course Offerings

Metrum Institute is pleased to announce several training course offerings for 2009! We've added two new courses this year: MI101: Introduction to Pharmacokinetics and Pharmacodynamics, and MI220: R Programming for Pharmacometrics. In addition, our popular introductory Bayesian modeling course (MI250) has been revised to include new material focused on the use of the new BUGS PK-PD model library. Please see www.metruminstitute.org/training for more details and for registration information. Academic/non-profit discounts are available. As always, Metrum Institute training course revenues support our non- profit research, development and service activities. - Thank you for your support. Graduate students / graduate advisors seeking to establish academic credit for Metrum Institute courses may contact me directly: [email protected] . Thank you. Marc Marc R. Gastonguay, Ph.D. [ [email protected] ] Scientific Director and Chairman Metrum Institute [ www.metruminstitute.org ] (apologies for duplicate postings) ---- Metrum Institute 2009 Training Courses ---- MI101: Introduction to Pharmacokinetics and Pharmacodynamics 3 Cr • Sep 14–Dec 23 2009 (12 weeks plus 1 make-up week) • Mon 7–9 pm, Wed 7–8 pm (1) • Live Webcast • MI101 provides a thorough introduction to fundamental concepts in pharmacokinetics and pharmacodynamics through lectures and problem-solving lab sessions emphasizing physiologic concepts and real-world applications. Content in this course is consistent with expectations for an introductory pharmacokinetics course in a professional Pharmacy curriculum. MI110: NMQUAL for NONMEM® Software Installation and Qualification No Cr • Multiple offerings: March 11, June 25, Sep 14, and Dec 9 2009 (1 session each) • 1–3 pm (1) • Live Webcast • MI110 demonstrates basic NMQual techniques on a Windows platform, with the aim of executing rapid, well characterized NONMEM® installations. MI120: Brief Introduction to R and MIfuns No Cr • Multiple Offerings: March 24 and 27; Sep 15 and 18 2009 (2 days each) • Tue 2–4 pm, Fri 2–4 pm • Live Webcast • MI120 is a brief but intensive hands-on introduction to the R language, with specific focus on functions and features useful in pharmacometrics. This course also includes an introduction to the MIfuns package, which is used in later courses for processing of NONMEM® runs and other modeling/simulation tasks. Students will be given access to a Metrum Institute web-application server for hands-on examples. MI210: Essentials of Population PK-PD Modeling and Simulation 3 Cr • Sep–Dec 2010, exact dates TBD (12 weeks plus 2 make-up weeks) • Tue 2–4 pm, Fri 2–3 pm (1) • Live Webcast • MI210 provides an extensive overview of topics in population pharmacokinetics and pharmacodynamics, including nonlinear-mixed effects modeling theory and implementation, data formatting requirements, population model development, model evaluation techniques, continuous PK-PD models, Monte Carlo simulation, and best practices. Instruction combines didactic lectures with hands-on exercises using R, MIfuns, and the NONMEM® software. Students will be given access to a Metrum Institute web-application server for hands-on examples. MI212: Advanced Topics in Population PK-PD Modeling and Simulation 3 Cr • Sep 8–Dec 17 2009, (12 weeks plus 1 make-up week) • Tue 2–4 pm, Fri 2–3 pm (1) • Live Webcast • MI212 builds upon the material covered in MI210. It provides a detailed overview of advanced topics in population pharmacokinetics and pharmacodynamics: inter-occasion variability, mixture models, truncated continuous data (BQL), nonlinear-pharmacokinetic models, models for parent and metabolite plasma and urine data, indirect-response pharmacodynamic models, models for tolerance, precursor pools, cell lifespan, and other semi- mechanistic systems, disease progression models, population PK study design, and clinical trial simulation. Instruction combines didactic lectures with hands-on exercises using R, MIfuns, and the NONMEM® software. Students will be given access to a Metrum Institute web- application server for hands-on examples. MI220: R Programming for Pharmacometrics 2 Cr • Feb 18–May 29 2009 (12 weeks plus 2 make-up weeks) • Wed and Fri 12–1 pm (1) • Live Webcast • MI220 covers introductory through intermediate-level R programming topics with a focus on pharmacometric applications through lectures and hands-on lab sessions. Topics include basic R language constructs, data import/export, writing scripts and functions, manipulating data objects, traditional and lattice graphics, and basic statistical methods. This course also makes extensive use of the MIfuns package to teach and implement tasks such as population PK data set assembly, post-processing of Maximum Likelihood and Bayesian modeling output, exploratory and report- quality graphics and tables, and automation of compute intensive methods, such as bootstrapping and posterior predictive check model qualification. Students will be given access to a Metrum Institute web- application server for hands-on examples. MI250: Introduction to Bayesian Modeling and Simulation and the BUGS PK-PD Model Library 3 Cr • June 3–5, 2009 • Wed–Fri 8:30 am–4:30 pm (1) • Location: Metrum Institute, Tariffville, CT • MI250 is an intensive, hands-on, 3-day course that provides an introduction to Bayesian modeling theory and the practical use of WinBUGS and R for PK-PD applications. In addition to basic concepts, this new course includes instruction on the BUGS PK- PD model library, an open-source tool developed by Metrum Institute. This library facilitates the implementation of population PK-PD models in WinBUGS for compartmental models described by algebraic, general linear and differential equations. Hands-on software requirements include WinBUGS and R (both freely available). Students will provide their own laptop computers. MI255: Exposure-Response Modeling of Categorical, Count and Time-to- Event Data Using Bayesian and Maximum Likelihood Methods 3 Cr • July 13-15, 2009 • Mon–Wed 8:30 am–4:30 pm (1) • Location: Metrum Institute, Tariffville, CT • MI255 is an intensive, hands-on, 3- day course providing an introduction to modeling of categorical, count, and time-to-event data, and the practical use of WinBUGS and NONMEM® for such applications. The course provides some basic theory and illustrates some of the advantages of using Bayesian methods for these types of data sets. Hands-on software requirements include WinBUGS and R (both freely available). Students will provide their own laptop computers. (1) All Times Eastern, US For more information and to register, please see: http://www.metruminstitute.org/training ©Metrum Institute 2008, 2009 • NONMEM® is licensed and distributed by ICON Development Solutions.