ADVAN 1 or ADVAN 2 for sublingual data

Group: I am trying to run a POPPK analysis on sublingual data for pediatric patients. NONMEM is very new for me. I am debating whether it is appropriate to use ADVAN 1 or ADVAN2 for subligual administration. Neither fit the concept perfectly. Should the CTL streams be modified in any way? Thanks in advance. Varsha Mehta, MS(CRDSA), Pharm.D., FCCP Clinical Associate Professor Pharmacy, Pediatrics and Communicable Diseases Clinical Pharmacist Neonatal Critical Care University of Michigan (O) 734-936-8985 (F) 734-936-6946 [email protected] ********************************************************** Electronic Mail is not secure, may not be read every day, and should not be used for urgent or sensitive issues