Questions Regarding the calculation of CWRES with NONMEM version 6.2

From: Susan Zhou Date: November 21, 2008 news Source: mail-archive.com
Hi, Everybody, I have used Andrew Hooker's code to calculate CWRES with NONMEM 6.1 before (the NONMEM verbatim code and the R code for calculation). Now our NONMEM has been upgraded to 6.2, and I am having problems with the calculation of CWRES using the same code. In my NONMEM code, for the error structure I used the following code for the combined error model $SIGMA 1 FIXED ... $PK ... PERR=THETA(5) AERR=THETA(6) ... $ERROR Y=F+(F*PERR + AERR)*EPS(1) with NONMEM 6.1 and 6.2 using the exact same control file (with the verbatim code for generating the matrices used for CWRES calculation included), the outputs of the matrices are different. When using NONMEM 6.1, the output sigma and sesigma matrices used for calculation of CWRES are non zero, and the NONMEM 6.2 outputs for these matrices are zero matrices. The zero matrices seems to be one of the problems in calculation of CWRES. I saw in one thread that Tom Ludden mentioned that NONMEM 6.2 can output the matrices used for calculation of CWRES directly in table format without using the verbatim code. Has anybody used that function in 6.2 and would be willing to share the code. Any help would be much appreciated. Regards, Susan
Nov 20, 2008 Susan Zhou Questions Regarding the calculation of CWRES with NONMEM version 6.2
Nov 21, 2008 Susan Zhou Questions Regarding the calculation of CWRES with NONMEM version 6.2
Nov 21, 2008 Sam Liao Re: Questions Regarding the calculation of CWRES with NONMEM version 6.2