Table configuration
Dear Users
I am new to NONMEM and have been reading the NONMEM manuals but am still
somewhat confused. Would appreciate any help.
I have concentration data following multiple dosing - so that patients are at
steady state.
My compartment model is 3 compartment (which includes the compartment into
which drug is administered).
A few questions:
My data table at present looks like - I have separated it out here to make it
easier to read (however it means that the columns are slightly out of
alignment)
ID DATE=DROP TIME AMT RATE CMT MVD EVID CON Some comments
to help you know what is going on.
1 9/26/2006 7.59 750 0 1 1 1 0
..Dose being taken at 8am and 8pm
1 9/26/2006 19.59 750 0 1 1 1 0
..Dose administered to compartment 1
1 9/27/2006 7.3 0 0 0 0 0 1.12
..Trough concentration
1 9/27/2006 7.59 750 0 1 1 1 0
1 9/27/2006 8.3 0 0 0 0 0 12.67
..Half-hour post dose concn etc up to 12 hours
1 9/27/2006 9 0 0 0 0 0 9.89
1 9/27/2006 9.29 0 0 0 0 0 7.42
1 9/27/2006 10 0 0 0 0 0 3.64
1 9/27/2006 10.3 0 0 0 0 0 2.62
1 9/27/2006 10.59 0 0 0 0 0 1.95
1 9/27/2006 12 0 0 0 0 0 0.98
1 9/27/2006 13 0 0 0 0 0 0.62
1 9/27/2006 13.59 0 0 0 0 0 0.64
1 9/27/2006 15 0 0 0 0 0 0.64
1 9/27/2006 16 0 0 0 0 0 0.59
1 9/27/2006 16.59 0 0 0 0 0 1.28
1 9/27/2006 18 0 0 0 0 0 1.62
1 9/27/2006 19 0 0 0 0 0 2.62
1 9/27/2006 19.59 0 0 0 0 0 3.03
Question 1: Do I need a column SS and if so what should I input for this?
I am using ADVAN6 TOL=3 and SS=6 in my subroutine.
Question 2: I suspect I should not use date and time - please advise.
Question 3: Am getting an error message which is telling me that I don't
have dose data and the run has stopped because of this.
Thanks in advance for any help.
Denny