Re: Why population PK approach is good for pooling data compared to Classical statistical analysis?

Ayyappa, As far as I know any 'classical statistical analysis' that one can do using regression can be done with NONMEM. It is also possible to do hypothesis testing on means (t-test, ANOVA), logistic regression and survival analysis. What kinds of 'classical statistical analysis' do you want to do that you cannot do with NONMEM? Nick ayyappa.5.chaturvedula > > Dear Group, > > Could anybody explain or direct me to some literature why population > PK approach allows us to pool data from different studies but no > classical statistical analysis? > > Regards, > Ayyappa Chaturvedula > GlaxoSmithKline > 1500 Littleton Road, > Parsippany, NJ 07054 > Ph:9738892200 -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand n.holford http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford