Scaling for pediatric study planning

Dear NM_Users, we have all been good students and listened to Nick when he told us again and again the rock-solid truths of allometry: Volume: *(WT/70) CL: *(WT/70)**0.75 any rate constant related to distribution or elimination: *(WT/70)**(-0.25) Here my questions: a) how do we allometrically scale a first-order rate constant of absorption after oral dosing? b) how do we allometrically scale a first-order rate constant of absorption from a subcutaneous injection site? Thank you for your thoughts, Joachim __________________________________________ Joachim GREVEL, Ph.D. MERCK SERONO International S.A. Exploratory Medicine 1202 Geneva Tel: +41.22.414.4751 Fax: +41.22.414.3059 Email: joachim.grevel ----------------------------------------- This message and any attachment are confidential, may be privileged or otherwise protected from disclosure and are intended only for use by the addressee(s) named herein. If you are not the intended recipient, you must not copy this message or attachment or disclose the contents to any other person. If you have received this transmission in error, please notify the sender immediately and delete the message and any attachment from your system. Merck Serono does not accept liability for any omissions or errors in this message which may arise as a result of E-Mail-transmission or for damages resulting from any unauthorized changes of the content of this message and any attachment thereto. If verification is required, please request a hard-copy version. Merck Serono does not guarantee that this message is free of viruses and does not accept liability for any damages caused by any virus transmitted therewith. --=_alternative 0047F7DEC12574C9_=--