modeling binary observations

> Dear All : > > I'd like to get your opinion on this: when modeling an event (0/1) that is > caused by an cumulative effect, 1. would cumulative AUC be a better predictor > than concentration, since CAUC can better capture the accumulative process? > 2. If CAUC is used, is there good ways to implement > mechanistic/semi-mechanistic models rather than empirical approaches for > binary data? > 3. Can the model results from CAUC be extrapolated to other trial designs, > why or why not? > Your input is appreciated. Thanks. > > Yi Zhang > Centocor > > >