How to scale PARAMETERs

From: Axel . Facius Date: August 26, 2008 technical Source: mail-archive.com
Hi there! During $ESTimation, NONMEM prints PARAMETER values. At iteration 0, these are all 'scaled' to 0.1. During long NONMEM runs I'm sometimes interested in seeing where my current estimate of parameters are, so I would like to re-scale them back. Unfortunately simple re-scalings like "parameter" * 10 * "Initial-estimate" do not work (except for iteration 0 ;-). If I do this for the parameters in the last iteration, I do not end up with the final parameter estimates..?! Does anybody know how to re-scale? Cheers, Axel Here some example: initial est.: 0.4715E+00 initial par.: 0.1000E+00 final par.: -0.5854E+00 final est.: 2.38E-01 taken from: [...] 0INITIAL ESTIMATE OF THETA: LOWER BOUND INITIAL EST UPPER BOUND 0.0000E+00 0.4715E+00 0.1000E+07 [...] MONITORING OF SEARCH: 0ITERATION NO.: 0 OBJECTIVE VALUE: 0.65915E+05 NO. OF FUNC. EVALS.:20 CUMULATIVE NO. OF FUNC. EVALS.: 20 PARAMETER: 0.1000E+00 .. GRADIENT: 0.1145E+06 ... [...] 0ITERATION NO.: 61 OBJECTIVE VALUE: -0.39051E+04 NO. OF FUNC. EVALS.:36 CUMULATIVE NO. OF FUNC. EVALS.: 2195 PARAMETER: -0.5854E+00 ... GRADIENT: 0.3601E+02 ... 0MINIMIZATION SUCCESSFUL [...] ************************************************************************************************************************ ******************** ******************** ******************** FINAL PARAMETER ESTIMATE ******************** ******************** ******************** ************************************************************************************************************************ THETA - VECTOR OF FIXED EFFECTS PARAMETERS ********* TH 1 ... 2.38E-01 ... ---------------------------------------------------------------------- Proprietary or confidential information belonging to Nycomed Group may be contained in this message. If you are not the addressee indicated in this message, please do not copy or deliver this message to anyone. In such case, please destroy this message and notify the sender by reply e-mail. Please advise the sender immediately if you or your employer do not consent to Internet e-mail for messages of this kind. Opinions, conclusions and other information in this message that pertain to the sender's employer and its products and services represent the opinion of the sender and do not necessarily represent or reflect the views and opinions of the employer.
Aug 26, 2008 Axel Facius How to scale PARAMETERs
Aug 26, 2008 Axel . Facius How to scale PARAMETERs
Aug 26, 2008 William Bachman RE: How to scale PARAMETERs
Aug 26, 2008 Nick Holford Re: How to scale PARAMETERs