RE: PPC

Hello NMUSERS, Let me just add one more thought on the bootstrap discussion. Sometimes when doing a bootstrap it happens that the runs terminate because of parameter estimates near to the boundary (e.g. values for OMEGA close to 0). When this happens in a considerable number of runs, lets say in 10% of the runs, how would you then calculate the CI for that parameter? Because the bootstrap parameter distribution derived from all runs - irrespective of their termination status - would then be bimodal with one mode close to the boundary. Best regards, Andreas. ____________________________ Andreas Lindauer University of Bonn Department of Clinical Pharmacy An der Immenburg 4 D-53121 Bonn phone:+49 228 73 5781 fax: +49 228 73 9757