Re: Michaelis-Menten model

Pavel, You dont give any background to help answer this question. But if the doses have different first-order absorption rates and the absorpion half-life is slower than the elimination half-life (flip-flop) then you may see dose dependent terminal half-lives. Nick [EMAIL PROTECTED] wrote: > Hello NONMEM users, > > The classic Michaelis-Menton model predicts the same terminal slopes for different doses. I tried to use indirect response models to account for different slopes, but it was not fruitful. Can you recomend a set of empirical or mecanistic models, which predict very different terminel slopes at different doses? Thanks! > > Pavel -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand [EMAIL PROTECTED] tel:+64(9)373-7599x86730 fax:+64(9)373-7090 http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford