Re: Mechanistic modeling of estrous cycle
Dear Nele,
I am aware of a few published articles that discuss mechanistic modeling of
at least some of the biological processes leading to ovulation (including
the involvement of LH and FSH). Maybe one of them would be of help since not
all were conducted in rats. I am citing a few below:
1- Clément F, Monniaux D, Stark J, Hardy K, Thalabard JC, Franks S, Claude
D. Mathematical model of FSH-induced cAMP production in ovarian follicles. *Am
J Physiol Endocrinol Metab. 2001 Jul;281(1):E35-53.
*2- Bristol-Gould SK, Kreeger PK, Selkirk CG, Kilen SM, Mayo KE, Shea LD,
Woodruff TK, Fate of the initial follicle pool: empirical and mathematical
evidence supporting its sufficiency for adult fertility. *Dev Biol. 2006 Oct
1;298(1):149-54. Epub 2006 Jun 18.
*3- Washington TM, Blum JJ, Reed MC, Conn PM. A mathematical model for LH
release in response to continuous and pulsatile exposure of gonadotrophs to
GnRH. *Theor Biol Med Model. 2004 Sep 24;1:9.
*
I hope this helps.
Regards,
*Murad Melhem, PhD*
*Associate Director PK/PD*
*Cognigen Corporation*
*Buffalo, NY
*
Quoted reply history
On Tue, May 6, 2008 at 9:31 AM, <[EMAIL PROTECTED]> wrote:
> Dear all,
>
> has anybody ever mechanistically modeled ovulation in rats or any other
> species, taking LH, FSH or progesterone into account and would be willing
> to share some code?
>
> Thank you and best regards
> Nele
> _________________________
> Dr. Nele Plock
> Bayer Schering Pharma AG
> Drug Metabolism & Pharmacokinetics
> Development Pharmacokinetics
> Scientific Expert Development Pharmacokinetics
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