multiple dose with unequal dosing intervals
Hi All,
I am trying to analyze a multiple dose oral PK data (with unequal dosing
intervals) using NONMEM. second dose is given 48 hrs after the first dose
and after that the drug is given on 12 hr dosing interval over 14 days.
There are 8 sampling points available in first 48 h and then one trough
sample is available after 7 days, and following last dose, 8 data points are
available for next 24 h.
the following is a representative of my data set
#ID TIME DV AMT ADDL II MDV 102 0 0 60 0 48 1 102 0.5 205 0 0 0 0 102 1
305 0 0 0 0 102 2 283 0 0 0 0 102 4 134 0 0 0 0 102 6 78.8 0 0 0 0 102 8
51.5 0 0 0 0 102 12 17.6 0 0 0 0 102 24 2.16 0 0 0 0 102 48 0 60 30 12 1 102
192 704 0 0 0 0 102 360 585 0 0 0 0 102 360.5 782 0 0 0 0 102 361 1070 0 0 0
0 102 362 1460 0 0 0 0 102 364 1270 0 0 0 0 102 366 965 0 0 0 0 102 368 652
0 0 0 0 102 372 433 0 0 0 0
my model is not runing due to data record error message, Can anybody please
help me setting up the data file?
Any inputs will be appreciated.
Thanks a lot,
Yuyan
graduate student