RE: free AUC

Hello You can calculate free AUC, as you have described, only if the relationship between total and free concentration is linear and the free fraction remain constant throughout the dosing interval. Fatemeh >===== Original Message From Khaled Nm <[EMAIL PROTECTED]> ===== >Dear nmusers, > >If i have only the AUC of a drug. Can I calculate the fAUC using the equation: fAUC=AUC * f ? where f stands for the free fraction of the drug ? >Is there another solution ? > >Regards >Kalan Fatemeh Akhlaghi, PharmD, PhD Associate Professor in Pharmacokinetics Biomedical and Pharmaceutical Sciences (BPS) University of Rhode Island 125 Fogarty Hall, 41 Lower College Road Kingston, RI 02881, USA Phone/Fax: (401) 874 9205/(401) 874 2181 Email: [EMAIL PROTECTED] Laboratory Website: http://www.uri.edu/pharmacy/faculty/aps/akhlaghi/index