Senior Scientist in Mathematical Modelling and Senior Scientist in Biostatistics

*Simcyp is a fast-growing, research-based company that provides consultancy, knowledge integration tools, algorithms, modelling solutions and databases relevant to drug development (implemented in its world known Simcyp(R) Population Based ADME Simulator) for its client base of major blue-chip pharmaceutical and biotechnology organisations.* The company focuses, in particular, on gathering information required for the modelling and simulation (M&S) of the time-course and fate of drugs (ADME) in patients using experimental data derived from *in vitro* systems such as isolated enzyme and cellular systems, dissolution media and so on. We are on course to become the global industry standard in predictive population ADME, consequently there is a continuous requirement for high quality scientists to join us, help in our expansion and share our success. We offer a unique and exciting mix of academic and commercial environments which encourages regular attendance at scientific meetings as part of continuous education programs. The projects are scientifically challenging yet focused on solving practical issues relevant to modern drug development. All scientists are expected to participate in writing scientific reports relevant to their work under the leadership of our world leading senior scientists within the group. *closing date Friday 4th July 2008** * ** Ref: Sim/Math/Biostat/05/09 We have two immediate openings for a biostatistician and a mathematician who are keen to apply their skills in the field of systems biology and drug development. The candidates should have some experience of Applied Mathematics, Biostatistics and Data Analysis. This may include numerical solution of stiff and high-dimensional differential equations, the application of advanced optimisation techniques, optimal study design theory, Bayesian approaches in parameter estimation of large scale non-linear time-varying systems. The successful applicant will join an internationally recognised, multidisciplinary team in which s/he will be expected to take part in developing models and algorithms within the current framework of modelling and simulation*.* *Requirements: * * * · Preferably a PhD (or equivalent experience) in a relevant field: PKPD/Pharmacometrics; Computational/Systems Biology; Bioinformatics and Data Analysis; Medical Statistics; Control Engineering or Applied Mathematics. · Demonstrable communication skills as evident by history of presenting in scientific meetings or publication in peer reviewed journals and good interpersonal and organizational skills. · Industrial experience and previous working and knowledge of the following software are advantageous: WinNonlin, Adapt, NONMEM, WinBUGS, MONOLIX or any other commonly used PKPD tools; mathematical analysis/simulation platforms such as Matlab, acslX; statistical software such as S-PLUS/R/SAS. · Some understanding of a programming language such Fortran/C/C++/C# is preferable but not essential. * * *Salary: * Very Competitive and flexible subject to experience plus pension contribution, health scheme etc. If you would be interested in joining our team please visit www.simcyp.comor email [EMAIL PROTECTED] for further information quoting ref. and where you saw the advert. Best Regards Masoud