Re: Missing time data

Huali, This sounds like an ideal data set to determine if there are any effects of genotype on CL/F. You dont really need NONMEM - just look at the doserate/conc (i.e. CL/F) means for each genotype and do an ANOVA. Of course you can make it fancier and include other covariates such as weight, sex (a genotype), race etc. It can be done with NONMEM or almost any statistics package that supports multiple regression. Nick Huali Wu wrote: > Dear all: > > I am trying to figure out if there is any effect of enzyme genotype on the PK of a drug and its active metabolites. But I don't know if I could use NONMEM to do this with my data. I have a dataset from multiple dose study. Drug was administered orally and only one sample was taken from each patient at steady state. Parent drug and three metabolites concentrations were measured. Each patient was genotyped. Time since last dose was not recorded because the maximum concentration and trough concentration varied only 3%. Could NONMEM be used for this analysis? Any comment will be highly appreciated. Best regards, Huali -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand [EMAIL PROTECTED] tel:+64(9)373-7599x86730 fax:+64(9)373-7090 www.health.auckland.ac.nz/pharmacology/staff/nholford