Re: Re: [NMUSERS] Questions on fitting pediatric PK data using NONMEM

From: Georg Hempel Date: March 26, 2008 technical Source: mail-archive.com
Dear Winnie, it is not advisable to "normalize" the data to body weight or body surface area. Instead, you should build a basic model without weight/BSA and try to use weight or BSA as covariate for the pharmacokinetic parameters. Also, you should test the allometric scaling approach (see Anderson et al. Clin Pharmacokin 33(5): 313-327 (1997). With best regards Georg -- Hochschuldozent Dr. Georg Hempel Institut fuer Pharmazeutische und Medizinische Chemie - Klinische Pharmazie - Hittorfstr. 58-62 48149 Muenster, Germany E-mail: [EMAIL PROTECTED]

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Mar 25, 2008 Winnie . Seto Re: [NMUSERS] Questions on fitting pediatric PK data using NONMEM
Mar 26, 2008 Georg Hempel Re: Re: [NMUSERS] Questions on fitting pediatric PK data using NONMEM
Mar 26, 2008 Krishna Devarakonda RE: Re: [NMUSERS] Questions on fitting pediatric PK data using NONMEM
Mar 26, 2008 Nick Holford Re: Re: [NMUSERS] Questions on fitting pediatric PK data using NONMEM
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