RE : output SE of population PK parameters in Nonmem
Hi Jin,
See in NONMEM help:
___________________________________________________________________
| |
| FINALIZATION EXAMPLE ($PRED AND $INFN) |
|_________________________________________________________________|
This example contains abbreviated code which can be inserted in a
$PRED or $INFN block. This code outputs final parameter estimates,
standard errors, minimum value of the objective function, and condi-
tional estimates of etas to various user files. The return codes from
Estimation and Covariance steps (zero for normal termination) are also
output.
IF (ICALL.EQ.3) THEN
DO WHILE(DATA)
IF (NEWIND.LE.1) WRITE (50,*) ETA
ENDDO
WRITE (51,*) OBJECT
WRITE (52,*) THETA
WRITE (53,*) SETHET
WRITE (54,*) OMEGA(BLOCK)
WRITE (55,*) SEOMEG(BLOCK)
WRITE (56,*) SIGMA(BLOCK)
WRITE (57,*) SESIGM(BLOCK)
WRITE (58,*) IERE,IERC
ENDIF
Alternatively, you take advantage of the fact that all those estimmates are
stored in Vectors and matrices of various COMMON:
COMMON /ROCM6/ THETAF(40),OMEGAF(30,30),SIGMAF(30,30)
COMMON /ROCM7/ SETH(40),SEOM(30,30),SESIG(30,30)
COMMON /ROCM8/ OBJECT
COMMON /ROCM9/ IERE,IERC
COMMON /CM12/ COV(2850)
and write your own INFN subroutine (see INFN help).
Best regards,
Pascal Girard, PhD
EA 3738, CTO
Fac Medecine Lyon-Sud, BP12
69921 OULLINS Cedex, France
[EMAIL PROTECTED]
Tel +33 (0)4 26 23 59 54 / Fax +33 (0)4 26 23 59 76
Master Recherche Lyon 1 Santé et Populations, Spécialité PhIT
http://master-sante-pop.univ-lyon1.fr/
>-----Message d'origine-----
Quoted reply history
>De : [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] De
>la part de Jin, Bo
>Envoyé : vendredi 1 février 2008 17:48
>À : [email protected]
>Objet : [NMusers] output SE of population PK parameters in Nonmem
>
>Dear all: I have a question. Is there any way to output the SE or SD of
>a population PK parameter estimate in Nonmem (say typical value of Cl)
>into some files which can be read by SAS or S-Plus etc.? (e.g. some
>excel or TAB files?)
>
>thanks,
>
>- Bo
>
>_____________________________________
>
>BO JIN
>Clinical Pharmacology Statistics
>Merck Research Labs
>Phone: 267-305-7876
>
>
>
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