MONOLIX 2.3
We are very pleased to announce the release 2.3 of MONOLIX.
MONOLIX 2.3 can be downloaded from the MONOLIX website:
http://software.monolix.org
Best regards,
Marc Lavielle and France Mentré
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New features proposed in the release 2.3 of MONOLIX:
1) The Michaelis-Menten of the PK library are MEX-files (the C++ ODE
solver we use is much faster than the MATLAB one) ,
2) New window to check and modify the initial values of the fixed-effects,
3) The individual parameters (conditional modes, conditional
expectations and conditional standard deviations) are estimated
separately of the population parameters with MCMC.
4) A fourth transition kernel is used in the MCMC algorithm (random
permutation over the subjects),
5) Some improvements for creating a stuctural model based on several
differential equations,
6) For model assessment purpose, the NPDE (Normalized Prediction
Distribution Errors) are computed and graphically displayed with the
weighted residuals,
7) A trend (linear and piecewise cubic) is displayed in several plots:
covariates, joint distribution of the random effects, weighted
residuals, NPDE,
8) The estimation of the log-likelihood is graphically displayed with
a 90% confidence interval as a function of the Monte-Carlo size,
9) It is possible to monitor and control the convergence of the
algorithms "on line". Try the buttons "jump", "stop", "20 more" in the
waiting bar when you run SAEM for estimating the population
parameters...
10) A folder "my scripts" contains an example of MATLAB script. This
m-file shows how to run the algorithms used in MONOLIX. We invite you
to write your own MATLAB scripts and share them with the MONOLIX
users,
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We recall that the full MATLAB version of MONOLIX requires version 7.x
of MATLAB. No toolbox are required.
If you don't use MATLAB, you can download the MATLAB Component Runtime
(version 7.5) from the MONOLIX website. This is not necessary if you
have already downloaded it...
If you use the MCR version 7.5, download Monolix_V23_C75.zip
If you use the MCR version 7.6, download Monolix_V23_C76.zip
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"""""""""""""""""""""""""""""""""""""""""""""""""""""""""
Marc Lavielle
Université Paris-Sud, Bat 425,
Equipe de Probabilités, Statistique et Modélisation
91405 Orsay Cedex
Tel: (33) 1 69 15 57 43
Fax: (33) 1 69 15 72 34
[EMAIL PROTECTED]
http://www.math.u-psud.fr/~lavielle
The MONOLIX project: http://www.monolix.org
GDR "Statistique et Santé" : http://gdr.statsante.fr
"""""""""""""""""""""""""""""""""""""""""""""""""""""""""
France Mentré
Professor of Biostatistics
INSERM U738 - Université Paris 7
UF de Biostatistiques – CHU Bichat Claude Bernard - AP-HP
UFR de Médecine - Site Bichat
16 rue Henri Huchard
75018 Paris, France
tel: 33 (0) 1 44 85 62 71
sec: 33 (0) 1 44 85 62 80
fax: 33 (0) 1 44 85 62 83
email : [EMAIL PROTECTED]
PFIM: www.pfim.biostat.fr
MONOLIX: www.monolix.org
npde: www.npde.biostat.fr