PK/PD analyses in toxicology for tox prediction in humans

From: Nele . Plock Date: November 05, 2007 technical Source: mail-archive.com
Dear all, in drug development, is anybody aware of examples of population PK/PD analyses in toxicology and how the resulting PKPD relation might be used for prediction of toxic effects in humans prior to first-in-man studies? Thanks and best regards Nele _________________________ Dr. Nele Plock Bayer Schering Pharma AG Drug Metabolism & Pharmacokinetics Development Pharmacokinetics Scientific Expert Development Pharmacokinetics D- 13342 Berlin Phone : +49-30-468 15146 Fax: +49-30-468 95146 [EMAIL PROTECTED] http://www.bayerscheringpharma.de Vorstand: Arthur J. Higgins, Vorsitzender | Werner Baumann, Andreas Busch, Ulrich Köstlin, Kemal Malik, Gunnar Riemann Vorsitzender des Aufsichtsrats: Werner Wenning Sitz der Gesellschaft: Berlin | Eintragung: Amtsgericht Charlottenburg 93 HRB 283