Re: Between Occasion variability
Thanks for the reply.
If I understand that correctly, it means that I have two different kinds of
occasions.
The first one is different studies where different dose levels are
administered. Same individual receiving different dose levels. (example 4
dose levels hence 4 occasions)
The second type is studies where different routes of administration is used.
(example 2 routes hence 2 occasions)
I would then have in total 6 occasions and the two different omega blocks
for these occasions. Or do I seem to miss the way occasions are defined ??
Thanks again
Quoted reply history
On Nov 12, 2007 12:03 PM, Rocio Lledo <[EMAIL PROTECTED]> wrote:
>
>
> Dear Navin,
>
> You can estimate BOV when not all your individuals have the same
> number of occasions.
> The important point is how you define the occasions, as in your case for a
> crossover study you will probably have similar conditions in
> the 4 studies. So that each OCC should be defined with the same conditions
> in your four studies, for instance: in study one, a new OCC is defined
> every
> time you give a new dose, it should be the same way for study two, and so
> forth. This way the BOV will describe the variability within a subject
> from
> one dose to the other. Similarly you can do this for daily or weekly OCC,
> depending on your study design.
> And the way to handle it is as you did it for a single study.
>
> Best regards,
>
>
> Rocío Lledó, PhD
> Division of Pharmacokinetics and Drug Therapy
> Department of Pharmaceutical Biosciences
> Uppsala University
> Biomedicum, Box 591
> Uppsala, 75124
> Sweden
> Tel (mobile): +46-073-7062271
> Tel (office): +46-018-4714304
>
>
>
--
--Navin