Re: Modeling a concentration curve with secondary peaks?

Xiaoli, Try a dual absorption compartment model e.g. with ADVAN6. Here is a 1comp with 2 absorption comps: $MODEL COMP = (ABS1) COMP = (ABS2) COMP = (CENTRAL) ....... $DES DADT(1) = -K13*A(1) DADT(2) = -K23*A(2) DADT(3) = K13*A(1) + K23*A(2) - KE*A(3) Give a full dose to each absorption compartment, estimate F1 and code F2 as: F2 = 1 - F1 You can then estimate lag/abs rate constants/transit model parameters for each absorption comp to catch the doubles. Hope this helps, Joe At 13:55 26/10/2007, Hou, Xiaoli Shirley (Shirley) wrote: >I need help for modeling a concentration curve with secondary peaks. What >models could I use? I tried two compartment models, but it couldn’t capture >the secondary peaks. Suggestions or recommendations are highly appreciated. > >Thanks. > >Dr. Xiaoli Shirley Hou >Senior Biometrician, Biometrics Research >Merck Research Labs WP53-120 >West Point PA 19486 >Phone (215) 652-7498 (first week of each month) >Phone (540) 381-9599 (rest of time) >Fax (215) 993-1835 > > > >------------------------------------------------------------------------------ >Notice: This e-mail message, together with any attachments, contains >information of Merck & Co., Inc. (One Merck Drive, Whitehouse Station, >New Jersey, USA 08889), and/or its affiliates (which may be known >outside the United States as Merck Frosst, Merck Sharp & Dohme or MSD >and in Japan, as Banyu - direct contact information for affiliates is >available at http://www.merck.com/contact/contacts.html) that may be >confidential, proprietary copyrighted and/or legally privileged. It is >intended solely for the use of the individual or entity named on this >message. If you are not the intended recipient, and have received this >message in error, please notify us immediately by reply e-mail and then >delete it from your system. > >