Re: Nonparametric method

Tom, Rik Schoemaker wrote: > > I'm trying to implement nonparametric population parameter estimation in > > NONMEM VI but I run into the following error message: > > > > NONPARAMETRIC ESTIMATE REQUESTED. BUT NO INDIVIDUAL RECORDS EXIST > > WITH DATA MODELED WITH ACTIVE ETA'S You wrote: > > Since Rik Schoemaker's original e-mail a few weeks ago, the code > > associated with the NONPARAMETRIC option has been reviewed. There are > > problems (bugs) that may reveal themselves when the data set contains > > individuals with different active etas. For example, a data set with > > some individuals receiving only IV doses while others receive only oral > > doses may exhibit this bug. For the individuals receiving only IV > > doses, the eta's associated with absorption-related parameter such > > as F1, ALAG1, KA will be nonactive. This example makes it reasonably clear what an 'ACTIVE ETA' is but there is no mention of 'ACTIVE ETA' in the NONMEM help. Perhaps you could consider adding this to the next release so that users can get some clues on how to interpret this error message. What is strange here is the error message seems to anticipate what you are now identifying as a bug. If you fix the bug with NP is there a situation where this error message can occur? Nick -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand [EMAIL PROTECTED] tel:+64(9)373-7599x86730 fax:+64(9)373-7090 www.health.auckland.ac.nz/pharmacology/staff/nholford