Additive model for IOV and IIV within a logit-transform
Dear NMusers,
In a paper by Kerbusch, Wählby, Milligan, & Karlsson (BJCP 56 (6), 639-652) the
authors state that: "The bioavailability (F) depended on the formulation
(immediate = IR or extended = CR), the dose, and CYP2D6 genotype.
Interindividual variation for FIR and FCR, and interoccasion variability for
FIR and FCR were described using additive models within a logit-transform" and
reported
VARIABILITY ESTIMATE (CV)
IIV F,IR 67% (20%)
IIV F,CR 67% (20%)
IOV F 37% (13%)
Could a kind NMuser please provide the additive model for IOV and IIV within a
logit-transform. MORE importantly, please elucidate the formula for computing
the variability estimate of IIV and IOV in F. The table footer states "F:
bioavailability centred at median dose". Does this mean that the reported
variability estimate is only relevant at the computed F value for the median
dose?
Thanking you in advance...MNS