Modeling enantiomeric and racemic concentrations simultaneously

ProgId Word.Document Generator Microsoft Word 10 Originator Microsoft Word 10 Dear all, I have conducted a pharmacokinetic study in rat and I have a question about how to model enantiomeric and racemic concentrations simultaneously. The study design was as follows: Sparse data (2 - 3 plasma samples, n=10 rats) was collected for the two enantiomers, and rich data for the racemate (10-15 plasma samples, n=4 rats) following oral administration. I would like to build an individual model for each enantiomer and use the racemic data to stabilize the sparse data I have on the enantiomers. Do you have any suggestions how this could be done and how such a control-file should be written? Kind regards, Rasmus Jansson _____________________________________________ Rasmus Jansson Unit for Pharmacokinetics and Drug Metabolism Göteborg University P.O.Box 431, SE-405 30 Göteborg Sweden Phone: +46(0)31 786 3240 Fax: +46 (0)31 786 3284