Standard error for estimates
Hello everybody
I am using Nonmem VI to model some Population Pk (10 subjects) data that I
have.
When I run this file.. I get the parameter estimates.
However I fail to get any STANDARD ERROR of the estimates.
I do sometimes get the R,S, T matrices when I change my initial estimates.
Also the output file has following messages
MINIMIZATION SUCCESSFUL
MATRIX ALGORITHMICALLY SINGULAR
AND ALGORITHMICALLY NON-POSITIVE-SEMIDEFINITE
0R MATRIX IS OUTPUT
0COVARIANCE STEP ABORTED
My understanding (maybe I got it wrong) is that these R,S, T matrices are
printed out when there are more than one solutions to the parameter
estimates.
is this right or does my control stream have some error within it.
I checked the individual plots with the output data file. The individual and
population predicted fits are quite decent..
It also gives me the following error message in the dos window
(WARNING 50) OPTION "UNCONDITIONAL" OF $COVARIANCE RECORD IS IGNORED WITH
THIS RELEASE OF NONMEM.
Could someone kindly help me with what is the error in my control stream or
how would I be able to get the Std error for the estimates
$PROBLEM PK
$INPUT ID TIME AMT MDV DV EVID CMT
$DATA file1.csv IGNORE=C
$SUBROUTINE ADVAN6 TRANS1 TOL=5
$MODEL
COMP=(DEPOT,DEFDOSE);
COMP=(CENTRAL);PLASMA
$PK
F1=THETA(1)*EXP(ETA(1)+ETA(2))
K12=4;Abso constant
TVCL=THETA(2);Clearance
CL=TVCL*EXP(ETA(3))
TVVC=THETA(3);vol of dist of drug
VC=TVVC*EXP(ETA(4))
K20=0.20;elim rate const of drug
VC=CL/K20
S2=VC; OUTPUT IN ng/ml
$ERROR
IPRED=F
IRES=DV-IPRED
DEL=0
IF (IPRED.EQ.0) DEL=1
IWRES=(1-DEL)*IRES/(IPRED+DEL)
Y=F+F*ERR(1)
$DES
DADT(1)=-K12*A(1)
DADT(2)=K12*A(1)-K20*A(2)
$THETA
(0.01,0.5,0.8); bioavailability
(75 FIXED);CL
(375 FIXED);VC
$OMEGA
$SIGMA
$ESTIMATION METHOD=1 SIGDIGITS=2 MAXEVAL=9999 PRINT=5 POSTHOC
$COVARIANCE UNCONDITIONAL
$TABLE ID TIME AMT MDV DV EVID CMT IPRED IWRES IRES
NOPRINT ONEHEADER FILE=sdtabsab335
thanks a lot