nonparametric estimation option

From: Julie Antic Date: May 13, 2007 technical Source: mail-archive.com
Dear NM users, I'd like to use the new nonparametric feature on NONMEM VI. If the help guides are quite clear about the implementation, I don't really understand how the estimates are computed : which objective function is it? Why jointly cumulatives function could not be obtained, in addition to marginals? Is anyone knows references which give more detailed informations about this option? Thanks in advance, Julie ANTIC Institut de Recherches Internationales Servier / Institut de Mathématiques de Toulouse UMR181 Physiopathologie et Toxicologie Expérimentales, INRA, ENVT 23 chemin des Capelles B.P. 87614 31076 Toulouse Cedex 3 Tel. 05 61 19 39 29 Fax. 05 61 19 39 17 [EMAIL PROTECTED] http://biostat.envt.fr/spip/spip.php?rubrique30
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