RE: parent drug and metabolite
Zheng,
When you edit your control stream, make sure there is no format issue that
NONMEM can not recognize.
Alan
Quoted reply history
-----Original Message-----
From: [EMAIL PROTECTED]
[mailto:[EMAIL PROTECTED] Behalf Of Zheng Lu
Sent: Sunday, March 04, 2007 12:48 PM
To: [email protected]
Subject: [NMusers] parent drug and metabolite
Dear All:
why do I get following error message with the following code? Any
opinions regarding this problem and code will be highly appreciated.
Thank you very much for your consideration and help. I am modeling
parent drug and active metabolite at the same time with this code.
AN ERROR WAS FOUND IN THE CONTROL STATEMENTS.
AN ERROR WAS FOUND ON LINE 13 AT THE APPROXIMATE POSITION NOTED:
CL1=THETA(1)*EXP(ETA(1))
X
THE CHARACTERS IN ERROR ARE:
202 FORTRAN SYNTAX IS INCORRECT OR INAPPROPRIATE IN THIS CONTEXT.
4
$PROBLEM Parent drug & active metabolite ;Units: Time=mins,
Concentration=uM(umols/L), Amount=umols
;Age=yrs, Weight=kg
$DATA AW2.CSV IGNORE=C $INPUT ID TIME DV ANUM AMT SEX WT AGE CMT EVID MDV
$SUBROUTINE ADVAN6 TRANS1 TOL=5
$MODEL
COMP=(PARENT) COMP=(METAB1) COMP=(METAB2)
$PK
CL1=THETA(1)*EXP(ETA(1))
V1=THETA(2)*EXP(ETA(2))
K20=THETA(3)*EXP(ETA(3))
Q=THETA(4)*EXP(ETA(4))
V2=THETA(5)*EXP(ETA(5))
V3=THETA(6)*EXP(ETA(6))
S1=V1
S2=V2
K12=CL1/V1
$DES
DADT(1)=-CL1*A(1)/V1
DADT(2)=CL1*A(1)/V1+Q/V3*A(3)-Q/V2*A(2)-K20*A(2)
DADT(3)=Q/V2*A(2)-Q/V3*A(3)
$ERROR
W=F
IPRED=F
IRES=DV-IPRED
IWRES=IRES/W
P1=0
IF(CMT.EQ.1)P1=1
P2=0
IF(CMT.EQ.2)P2=1
Y1=W*(1+ERR(1))
Y2=W*(1+ERR(2))
Y=P1*Y1+P2*Y2
$THETA
(0,,0.1000E+07)
(0,,0.1000E+07)
(0,,0.1000E+07)
(0,,0.1000E+07)
(0,,0.1000E+07)
(0,,0.1000E+07)
(0,,0.1000E+07)
(0,,0.1000E+07)
$OMEGA
(0,,0.1000E+07)
(0,,0.1000E+07)
(0,,0.1000E+07)
(0,,0.1000E+07)
(0,,0.1000E+07)
(0,,0.1000E+07)
(0,,0.1000E+07)
$SIGMA
(0,,0.1000E+07)
(0,,0.1000E+07)
$ESTIMATION MAXEVAL=9999 PRINT=5 POSTHOC
$COVARIANCE
$TABLE ID TIME DV ANUM AMT SEX WT AGE CMT EVID MDV IPRED IWRES
NOPRINT ONEHEADER FILE=OUTAMIWR.FIT
ID Time DV Anum AMT Gender WT Age CMT
1 0 0 1 3371.43 F 110.23 44 1
1 1 187 1 0 F 110.23 44 1
1 1 14.24 1 0 F 110.23 44 2
1 5 85.55 1 0 F 110.23 44 1
1 5 28.49 1 0 F 110.23 44 2
1 15 12.1 1 0 F 110.23 44 1
1 15 13.43 1 0 F 110.23 44 2
1 30 1.03 1 0 F 110.23 44 1
1 30 3.25 1 0 F 110.23 44 2
1 45 1.19 1 0 F 110.23 44 2
1 60 0.83 1 0 F 110.23 44 2
1 120 0.4 1 0 F 110.23 44 2
1 180 0.35 1 0 F 110.23 44 2
1 240 0.13 1 0 F 110.23 44 2
Zheng