Distribution of NONMEM VI

From: "Ludden, Thomas (MYD)" luddent@iconus.com Subject: [NMusers] Distribution of NONMEM VI Date: Thu, 30 Nov 2006 09:34:36 -0500 Dear all: Icon Development Solutions is now distributing NONMEM VI to all currently licensed sites. During the initial post-distribution period, if you encounter unexpected results when using NONMEM VI, please contact me directly at luddent@globomaxnm.com or (410) 696-3040. The transformation of parameters used in the estimation step is different from that used in NONMEM V; therefore, gradients in the intermediate output will differ from those in NONMEM VI. Results for CONTROL3 - 5 examples (provided with the distribution) using NONMEM VI are available at the NONMEM ftp site ftp://ftp.globomaxnm.com/Public/nonmem/ in a folder named StdresultsNONMEMVI. The conditional estimation of interindividual random terms, ETA's, also differs. For conditional estimation methods, NONMEM VI is numerically more stable and frequently provides shorter run-times than NONMEM V. However, on occasion and with specific problems, NONMEM V may prove to be useful in finding a stable, minimum objective function. We encourage all current users to maintain their installation of NONMEM V while they explore the performance and new features of NONMEM VI. As long as NONMEM VI is installed into a different directory there will be no conflict between the two version. If CDSETUP6.bat is used, the default directory for NONMEM VI is nmvi. Tom Ludden Icon Development Solutions _______________________________________________________