RE : Con't: fast and slow absorption

From: Sam Liao sliao@pharmaxresearch.com Subject: RE : [NMusers] Con't: fast and slow absorption Date: Wed, 15 Nov 2006 15:14:08 -0500 Jian: Here is an example NONMEM control stream for the pk model you need. Please make sure to specify CMT=3 for your PK data. You also need one dose event record with CMT=1 and the second dose event record with CMT=2. The AMT will be the same in both records. Best regards, Sam Liao Pharmax Research ========================================================= $PROB PHARMACOKINETIC MODEL 1-CMPT WITH ONE SLOW AND ONE FAST ABSORPTION $INPUT ID TIME DAY AMT CONC=DV CMT AGE WT SEX RACE $DATA nm.prn IGNORE=# $SUBROUTINE ADVAN6 TOL=6 $MODEL NCOMP=3 COMP=(DEPOT1,DEFDOSE) COMP=(DEPOT2) COMP=(CENT,DEFOBS) $PK TVCL= THETA(1) TVVD= THETA(2) TKA1= THETA(3) TKA2= THETA(4) TF1 =THETA(5) TLAG= THETA(6) CL = TVCL*EXP(ETA(1)) V = TVVD*EXP(ETA(2)) KA1 = TKA1*EXP(ETA(3)) KA2 = TKA2*EXP(ETA(4)) F1 = TF1 *EXP(ETA(5)) IF (F1.GT.1) F1=0.999 F2 = 1 - F1 ALAG1=TLAG + ETA(6) IF (ALAG1.LE.0) ALAG1=0 ALAG2 = ALAG1 K30 = CL/V S3 = V ;ODE OF THE DECONJUGATION MODEL $DES DADT(1)= -KA1*A(1) ; KA1 DADT(2)= -KA2*A(2) ; KA2 DADT(3)= KA1*A(1) +KA2*A(2)-K30*A(3) ; CP $ERROR Y=F*(1+ERR(1)) + ERR(2) IPRE= F IRES= DV - IPRE $THETA (1,25,100) ;1 CL (100,400,900) ;2 V (0.1,.3,5) ;3 KA1 (0.001,.1,.3) ;4 KA2 (0.1,.5,1) ;5 F1 0 FIX ;6 TLAG $OMEGA 0.1 ;1 VAR IN CL 0.1 ;2 VAR IN V 0.1 ;3 VAR IN KA1 0.1 ;4 VAR IN KA2 0.1 ;5 VAR IN F1 0. FIX ;6 VAR IN TLAG $SIGMA 0.1 1.0 $EST SIG=3 MAXEVAL=9999 PRINT=5 METHOD=0 POSTHOC NOABORT $COV $TABLE ID TIME MDV K30 KA1 KA2 CL V ALAG1 F1 IPRE IRES ONEHEADER NOPRINT FILE=fit