NONMEM sparse data advantage reference

From: Joern Loetsch j.loetsch@em.uni-frankfurt.de Subject: [NMusers] NONMEM sparse data advantage reference Date: Thu, 02 Nov 2006 07:22:31 +0100 Dear NONMEM users, The NONMEM approach is especially better than the two-stage approach to estimate the PK of some drug in a sparse data situation. Not speaking of its other advantages. I fail to remember a reference for this. Could you please help me out. Thank you in advance. Jrn Ltsch -- _______________________________________________________ Univ.-Prof. Dr. med. Jrn Ltsch pharmazentrum frankfurt/ZAFES Institut fr Klinische Pharmakologie Johann Wolfgang Goethe-Universitt Theodor-Stern-Kai 7 D-60590 Frankfurt am Main Tel.:069-6301-4589 Fax.:069-6301-7636 http://www.klinik.uni-frankfurt.de/zpharm/klin/