Bootstrap question

From: Ivan Nestorov Date: September 22, 2006 technical Source: cognigencorp.com
From: "INTV (Ivan Nestorov)" nestorvi@zgi.com Subject: [NMusers] Bootstrap question Date: Fri, 22 Sep 2006 15:30:23 -0700 Dear NONMEM, I would like to bootstrap a dataset that includes 4 dosing arms with 15, 20, 15, and 25 subjects in each arm respectively. Do I bootstrap from within each arm so that I have the above sample sizes per arm in each bootstrap file or I just bootstrap the data as a whole and leave the distribution of subjects across the four arms to the random number generators. Thanks. Ivan Nestorov
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